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Study 3: Pharmacological Dissection Identifies Retatrutide Overcomes the Therapeutic Barrier of Obese TNBC Treatments through Suppressing the Interplay between Glycosylation and Ubiquitylation of YAP Authors : Xin Cui, Yueming Zhu, Lidan Zeng, Mengyuan Zhang, Amad Uddin, Theresa W Gillespie, Lauren E McCullough, Shaying Zhao, Mylin A Torres, Yong Wan Source : Scientific Findings This study elucidates a molecular mechanism by which Retatrutide overcomes therapeutic resistance in obese triple-negative breast cancer (TNBC)
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Subsequently, in murine formalin models, intrathecal injection of GLP-1(7–36) at a variety of doses significantly reduced the tonic flinching response in a dose-dependent manner, with no effects on acute nociceptive responses [24]
